Bone Cellular and Vascular Organization

Project 1: Synergistic use of SRµCT and Laser Scanning Confocal Microscopy to evaluate sex-related differences in the human osteocyte lacunar-canalicular network (LCN) across the lifespan (Figure 1)

Project 2: The visualization and description of vascular canal branching patterns among adult human bone types

Project 3: Regional patterns of vascularity within the humeri and femora of large and small-bodied bats

Figure 1: Confocal Laser Scanning Microscopy can generate 3D isosurfaces of the osteocyte lacunar canalicular network, as seen in this comparison of osteocyte lacunar network volume in a 21-year-old female (left) and 101-year-old female (right). (Photo Credit: JM Andronowski).

Forensic Anthropological Applications of 3D Bone Imaging

Project 1: Occurrence of osteon banding in adult human cortical bone

Project 2: Evaluating the relationship between bone cellular density and nuclear DNA yield rates

Project 3: Investigating the prolonged impact of opioid abuse on bone remodeling

Four-dimensional Imaging of Cortical Bone Remodeling In Vivo

Project 1: PTH dosing as a model system for inducing and tracking bone remodeling in the rabbit

© Andronowski Lab 

3D Render of Cortical Bone

Purple: Lacunar spaces Green: Vasculature