Research
Bone Cellular and Vascular Organization
Project 1: Synergistic use of SRµCT and Laser Scanning Confocal Microscopy to evaluate sex-related differences in the human osteocyte lacuno-canalicular network (LCN) across the lifespan (Figure 1)
Project 2: The visualization and description of vascular canal branching patterns among adult human bone types
Project 3: Interskeletal variability and allometry of 3D bacular and humeral microarchitecture in male harp seals, Phoca groenlandica
Figure 1: Confocal Laser Scanning Microscopy can generate 3D isosurfaces of the osteocyte lacunar canalicular network, as seen in this comparison of osteocyte lacunar network volume in a 21-year-old female (left) and 101-year-old female (right). (Photo Credit: JM Andronowski).
Forensic Anthropological Applications of 3D Bone Imaging
Project 1: Occurrence of osteon banding in adult human cortical bone
Project 2: Evaluating the relationship between bone cellular density and nuclear DNA yield rates
Project 3: Investigating the prolonged impact of opioid abuse on bone remodeling
Project 4: Automated deep learning approaches to the segmentation of vascular pore systems and osteocyte lacunae in virtual and traditional histologic datasets
Four-dimensional Imaging of Cortical Bone Remodeling In Vivo
Project 1: PTH dosing as a model system for inducing and tracking bone remodeling in the rabbit
