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Bone Cellular and Vascular Organization

Project 1: Synergistic use of SRµCT and Laser Scanning Confocal Microscopy to evaluate sex-related differences in the human osteocyte lacuno-canalicular network (LCN) across the lifespan (Figure 1)

Project 2: The visualization and description of vascular canal branching patterns among adult human bone types

Project 3: Interskeletal variability and allometry of 3D bacular and humeral microarchitecture in male harp seals, Phoca groenlandica

Figure 1: Confocal Laser Scanning Microscopy can generate 3D isosurfaces of the osteocyte lacunar canalicular network, as seen in this comparison of osteocyte lacunar network volume in a 21-year-old female (left) and 101-year-old female (right). (Photo Credit: JM Andronowski).

Forensic Anthropological Applications of 3D Bone Imaging

Project 1: Occurrence of osteon banding in adult human cortical bone

Project 2: Evaluating the relationship between bone cellular density and nuclear DNA yield rates

Project 3: Investigating the prolonged impact of opioid abuse on bone remodeling

Project 4: Automated deep learning approaches to the segmentation of vascular pore systems and osteocyte lacunae in virtual and traditional histologic datasets

Four-dimensional Imaging of Cortical Bone Remodeling In Vivo

Project 1: PTH dosing as a model system for inducing and tracking bone remodeling in the rabbit

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