Bone Cellular and Vascular Organization

Project 1: Synergistic use of SRµCT and Laser Scanning Confocal Microscopy to evaluate sex-related differences in the human osteocyte lacunar-canalicular network (LCN) across the lifespan (Figure 1)

Project 2: The visualization and description of vascular canal branching patterns among adult human bone types

Project 3: Regional patterns of vascularity within the humeri and femora of large and small-bodied bats

Figure 1: Confocal Laser Scanning Microscopy can generate 3D isosurfaces of the osteocyte lacunar canalicular network, as seen in this comparison of osteocyte lacunar network volume in a 21-year-old female (left) and 101-year-old female (right). (Photo Credit: JM Andronowski).

Forensic Anthropological Applications of 3D Bone Imaging

Project 1: Occurrence of osteon banding in adult human cortical bone

Project 2: Evaluating the relationship between bone cellular density and nuclear DNA yield rates

Project 3: Investigating the prolonged impact of opioid abuse on bone remodeling

Four-dimensional Imaging of Cortical Bone Remodeling In Vivo

Project 1: PTH dosing as a model system for inducing and tracking bone remodeling in the rabbit

© Andronowski Lab 

Micro-CT 3D: Midshaft sixth rib

3D reconstruction of the cortex (upper left), trabecular architecture (upper right), cortical pore networks coloured by local thickness (lower left), and maps of pore separation (lower right). Scale = 1000 μm.